8C8J

Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP

Summary for 8C8J

• Entry DOI: 10.2210/pdb8c8j/pdb
• Descriptor: RNA-directed DNA polymerase, CHLORIDE ION, DNA (5'-D(P*GP*CP*GP*CP*TP*TP*TP*CP*C)-3'), ... (11 entities in total)
• Functional Keywords: reverse transcriptase, rt, dttp, hyrbid duplex, template primer, replication
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 106642.63

Authors

Nichols, C.E.,Walpole, T.B.,Baldwin, E. (deposition date: 2023-01-20, release date: 2023-12-20, Last modification date: 2024-02-14)

• Primary citation: Baldwin, E.T.,van Eeuwen, T.,Hoyos, D.,Zalevsky, A.,Tchesnokov, E.P.,Sanchez, R.,Miller, B.D.,Di Stefano, L.H.,Ruiz, F.X.,Hancock, M.,Isik, E.,Mendez-Dorantes, C.,Walpole, T.,Nichols, C.,Wan, P.,Riento, K.,Halls-Kass, R.,Augustin, M.,Lammens, A.,Jestel, A.,Upla, P.,Xibinaku, K.,Congreve, S.,Hennink, M.,Rogala, K.B.,Schneider, A.M.,Fairman, J.E.,Christensen, S.M.,Desrosiers, B.,Bisacchi, G.S.,Saunders, O.L.,Hafeez, N.,Miao, W.,Kapeller, R.,Zaller, D.M.,Sali, A.,Weichenrieder, O.,Burns, K.H.,Gotte, M.,Rout, M.P.,Arnold, E.,Greenbaum, B.D.,Romero, D.L.,LaCava, J.,Taylor, M.S.; Structures, functions and adaptations of the human LINE-1 ORF2 protein.; Nature, 626:194-206, 2024; PubMed: 38096902; DOI: 10.1038/s41586-023-06947-z

Experimental method

X-RAY DIFFRACTION (2.1 Å)