8BOY

X-ray structure of the adduct formed upon reaction of the five-coordinate Pt(II) complex, 1-Me,Me, with HEWL at pH 4.0

This is a non-PDB format compatible entry.

Summary for 8BOY

• Entry DOI: 10.2210/pdb8boy/pdb
• Descriptor: Lysozyme C, NITRATE ION, 1-[1,3-dimethyl-4-(1~{H}-1,2,3-triazol-5-yl)imidazol-1-ium-2-yl]-1,2',11'-trimethyl-spiro[1$l^{6}-platinacycloprop-2-ene-1,15'-1,12-diaza-15$l^{6}-platinatetracyclo[10.2.1.0^{5,14}.0^{8,13}]pentadeca-2,4,6,8,10,13-hexaene], ... (5 entities in total)
• Functional Keywords: platinum, five-coordinate, glucoconjugate, metallodrug, protein interaction, hydrolase
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 1
• Total formula weight: 15753.88

Authors

Ferraro, G.,Tito, G.,Merlino, A. (deposition date: 2022-11-15, release date: 2023-02-22, Last modification date: 2024-02-07)

• Primary citation: Annunziata, A.,Imbimbo, P.,Cucciolito, M.E.,Ferraro, G.,Langellotti, V.,Marano, A.,Melchiorre, M.,Tito, G.,Trifuoggi, M.,Monti, D.M.,Merlino, A.,Ruffo, F.; Impact of Hydrophobic Chains in Five-Coordinate Glucoconjugate Pt(II) Anticancer Agents.; Int J Mol Sci, 24:-, 2023; PubMed: 36768690; DOI: 10.3390/ijms24032369

Experimental method

X-RAY DIFFRACTION (1.33 Å)