8A49

Endoglycosidase S in complex with IgG1 Fc

Summary for 8A49

Entry DOI	10.2210/pdb8a49/pdb
Descriptor	IgG1 Fc, Secreted endoglycosidase EndoS, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	endoglycosidase, antibody, complex, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	257490.20
Authors	Sudol, A.S.L.,Tews, I.,Crispin, M. (deposition date: 2022-06-10, release date: 2022-11-30, Last modification date: 2024-01-31)
Primary citation	Sudol, A.S.L.,Butler, J.,Ivory, D.P.,Tews, I.,Crispin, M. Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS. Nat Commun, 13:7801-7801, 2022 Cited by PubMed: 36528711 DOI: 10.1038/s41467-022-35340-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.45 Å)

Structure validation