8A49
Endoglycosidase S in complex with IgG1 Fc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
| C | 0042783 | biological_process | evasion of host immune response |
| C | 0043655 | cellular_component | host extracellular space |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0090729 | molecular_function | toxin activity |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
| D | 0042783 | biological_process | evasion of host immune response |
| D | 0043655 | cellular_component | host extracellular space |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0090729 | molecular_function | toxin activity |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCSVMH |
| Chain | Residue | Details |
| A | PHE423-HIS429 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19358553 |
| Chain | Residue | Details |
| A | ASN297 | |
| B | ASN297 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29760474, ECO:0007744|PDB:6EN3 |
| Chain | Residue | Details |
| C | HIS151 | |
| C | TRP153 | |
| C | ARG186 | |
| C | ASP237 | |
| C | GLN303 | |
| C | TYR305 | |
| C | GLU349 | |
| C | GLU350 | |
| C | ASN356 | |
| C | TYR402 | |
| D | HIS151 | |
| D | TRP153 | |
| D | ARG186 | |
| D | ASP237 | |
| D | GLN303 | |
| D | TYR305 | |
| D | GLU349 | |
| D | GLU350 | |
| D | ASN356 | |
| D | TYR402 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24753590, ECO:0000269|PubMed:29760474, ECO:0007744|PDB:4NUY, ECO:0007744|PDB:4NUZ, ECO:0007744|PDB:6EN3 |
| Chain | Residue | Details |
| C | LYS786 | |
| C | ASP789 | |
| C | GLN791 | |
| C | PRO915 | |
| D | LYS786 | |
| D | ASP789 | |
| D | GLN791 | |
| D | PRO915 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24753590, ECO:0007744|PDB:4NUZ |
| Chain | Residue | Details |
| C | GLU916 | |
| D | GLU916 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by S.pyogenes SpeB => ECO:0000269|PubMed:18182097 |
| Chain | Residue | Details |
| C | LEU445 | |
| D | LEU445 |
