7Z4V

Structure of Serine-Threonine kinase STK25 in complex with compound

Summary for 7Z4V

Entry DOI	10.2210/pdb7z4v/pdb
Descriptor	Serine/threonine-protein kinase 25, ~{N}-(5-~{tert}-butyl-1~{H}-pyrazol-3-yl)-4-pyrrolidin-1-ylsulfonyl-benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	tumor suppressor, phosphorylation, yap/taz, kinase, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34356.28
Authors	Nawrotek, A.,Vuillard, L.,Miallau, L. (deposition date: 2022-03-04, release date: 2022-04-06, Last modification date: 2024-01-31)
Primary citation	Kiyeleko, S.,Hocine, S.,Mautino, G.,Kuenemann, M.,Nawrotek, A.,Miallau, L.,Vuillard, L.M.,Mirguet, O.,Kotschy, A.,Hanessian, S. Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25. Bioorg.Med.Chem.Lett., 75:128950-128950, 2022 Cited by PubMed: 36030002 DOI: 10.1016/j.bmcl.2022.128950 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.644 Å)

Structure validation