7YXU

Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB.

Summary for 7YXU

• Entry DOI: 10.2210/pdb7yxu/pdb
• Descriptor: Tumor necrosis factor receptor superfamily member 9, heavy chain of Fab, light chain of Fab, ... (6 entities in total)
• Functional Keywords: complex, fab, tumor necrosis factor, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 62900.97

Authors

Hakansson, M.,Rose, N.,Petersson, J.,Enell Smith, K.,Thorolfsson, M.,von Schantz, L. (deposition date: 2022-02-16, release date: 2023-01-25, Last modification date: 2024-02-07)

• Primary citation: Nelson, M.H.,Fritzell, S.,Miller, R.,Werchau, D.,Van Citters, D.,Nilsson, A.,Misher, L.,Ljung, L.,Bader, R.,Deronic, A.,Chunyk, A.G.,Schultz, L.,Varas, L.A.,Rose, N.,Hakansson, M.,Gross, J.,Furebring, C.,Pavlik, P.,Sundstedt, A.,Veitonmaki, N.,Ramos, H.J.,Sall, A.,Dahlman, A.,Bienvenue, D.,von Schantz, L.,McMahan, C.J.,Askmyr, M.,Hernandez-Hoyos, G.,Ellmark, P.; The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies.; Mol.Cancer Ther., 22:89-101, 2023; PubMed: 36343381; DOI: 10.1158/1535-7163.MCT-22-0395

Experimental method

X-RAY DIFFRACTION (2.31 Å)