7Y9Z

Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (one-RBD-up state)

Summary for 7Y9Z

• Entry DOI: 10.2210/pdb7y9z/pdb
• EMDB information: 33697
• Descriptor: Spike glycoprotein, Processed angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: omicron, ace2, sars-cov-2, one rbd up, virus, viral protein-hydrolase complex, viral protein/hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 4
• Total formula weight: 502788.62

Authors

Gao, G.F.,Qi, J.X.,Liu, S.,Zhao, Z.N. (deposition date: 2022-06-26, release date: 2022-09-21)

• Primary citation: Zhao, Z.,Zhou, J.,Tian, M.,Huang, M.,Liu, S.,Xie, Y.,Han, P.,Bai, C.,Han, P.,Zheng, A.,Fu, L.,Gao, Y.,Peng, Q.,Li, Y.,Chai, Y.,Zhang, Z.,Zhao, X.,Song, H.,Qi, J.,Wang, Q.,Wang, P.,Gao, G.F.; Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.; Nat Commun, 13:4958-4958, 2022; PubMed: 36002453; DOI: 10.1038/s41467-022-32665-7

Experimental method

ELECTRON MICROSCOPY (2.85 Å)