7Y26

Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex

Summary for 7Y26

• Entry DOI: 10.2210/pdb7y26/pdb
• Related: 7Y24
• EMDB information: 33586
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Octreotide, ... (6 entities in total)
• Functional Keywords: gpcr, g protein, biased ligand, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 139363.11

Authors

Chen, S.,Zheng, S. (deposition date: 2022-06-09, release date: 2022-10-19, Last modification date: 2023-02-15)

• Primary citation: Chen, S.,Teng, X.,Zheng, S.; Molecular basis for the selective G protein signaling of somatostatin receptors.; Nat.Chem.Biol., 19:133-140, 2023; PubMed: 36138141; DOI: 10.1038/s41589-022-01130-3

Experimental method

ELECTRON MICROSCOPY (3.3 Å)