7XYH

Crystal structure of CK2a2 complexed with AG1112

Summary for 7XYH

• Entry DOI: 10.2210/pdb7xyh/pdb
• Descriptor: Casein kinase II subunit alpha', 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 81613.34

Authors

Ikeda, A.,Kinoshita, T.,Tsuyuguchi, M. (deposition date: 2022-06-01, release date: 2023-01-18, Last modification date: 2023-11-29)

• Primary citation: Ikeda, A.,Tsuyuguchi, M.,Kitagawa, D.,Sawa, M.,Nakamura, S.,Nakanishi, I.,Kinoshita, T.; Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2 alpha 1-selective inhibitors.; Biochem.Biophys.Res.Commun., 630:30-35, 2022; PubMed: 36130444; DOI: 10.1016/j.bbrc.2022.09.040

Experimental method

X-RAY DIFFRACTION (2.04 Å)