7XMF

Cryo-EM structure of human NaV1.7/beta1/beta2-Nav1.7-IN2

Summary for 7XMF

• Entry DOI: 10.2210/pdb7xmf/pdb
• EMDB information: 33295
• Descriptor: Isoform 3 of Sodium channel protein type 9 subunit alpha,Green fluorescent protein, Sodium channel subunit beta-1,Green fluorescent protein, Sodium channel subunit beta-2, ... (6 entities in total)
• Functional Keywords: sodium channel, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 337091.39

Authors

Zhang, J.T.,Jiang, D.H. (deposition date: 2022-04-25, release date: 2022-11-30, Last modification date: 2022-12-28)

• Primary citation: Zhang, J.,Shi, Y.,Huang, Z.,Li, Y.,Yang, B.,Gong, J.,Jiang, D.; Structural basis for Na V 1.7 inhibition by pore blockers.; Nat.Struct.Mol.Biol., 29:1208-1216, 2022; PubMed: 36424527; DOI: 10.1038/s41594-022-00860-1

Experimental method

ELECTRON MICROSCOPY (3.07 Å)