7XMF

Cryo-EM structure of human NaV1.7/beta1/beta2-Nav1.7-IN2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isoform 3 of Sodium channel protein type 9 subunit alpha,Green fluorescent protein	polymer	2250	255679.9	1	UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) In PDB	Homo sapiens (human)
2	B	Sodium channel subunit beta-1,Green fluorescent protein	polymer	481	54472.1	1	UniProt (Q07699) Pfam (PF07686) In PDB	Homo sapiens (human)
3	C	Sodium channel subunit beta-2	polymer	215	24355.9	1	UniProt (O60939) Pfam (PF07686) In PDB	Homo sapiens (human)	Nav1.7 beta2 subunit
4	D, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	A	3-[[4-[3-(4-fluoranyl-2-methyl-phenoxy)azetidin-1-yl]pyrimidin-2-yl]amino]-~{N}-methyl-benzamide	non-polymer		407.4	1	Chemie (G2W)

Sequence modifications

A: 1 - 1988 (UniProt: Q15858)

PDB	External Database	Details
Arg 1161	Trp 1150	engineered mutation
Ala 1989	-	linker
Ala 1990	-	linker
Ala 1991	-	linker
Leu 1992	-	linker
Glu 1993	-	linker
Val 1994	-	linker
Leu 1995	-	linker
Phe 1996	-	linker
Gln 1997	-	linker
Gly 1998	-	linker
Pro 1999	-	linker
Ser 2000	-	linker

A: 2001 - 2261 (PDB: 7XMF)
B: 1 - 218 (UniProt: Q07699)

PDB	External Database	Details
Ala 219	-	linker
Ala 220	-	linker
Ala 221	-	linker
Leu 222	-	linker
Glu 223	-	linker
Val 224	-	linker
Leu 225	-	linker
Phe 226	-	linker
Gln 227	-	linker
Gly 228	-	linker
Pro 229	-	linker
Ser 230	-	linker

B: 231 - 481 (PDB: 7XMF)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	334507.9
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	7
	Total formula weight	1734.7
All*	Total formula weight	337091.4

*Water molecules are not included.