7WGE

Human NLRP1 complexed with thioredoxin

Summary for 7WGE

Entry DOI	10.2210/pdb7wge/pdb
EMDB information	32484
Descriptor	NACHT, LRR and PYD domains-containing protein 1, N-terminus, Thioredoxin, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	nlrp1, inflammasome, thioredoxin, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	114492.39
Authors	Zhang, Z.,Ohto, U.,Shimizu, T. (deposition date: 2021-12-28, release date: 2023-07-05, Last modification date: 2023-10-18)
Primary citation	Zhang, Z.,Shibata, T.,Fujimura, A.,Kitaura, J.,Miyake, K.,Ohto, U.,Shimizu, T. Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature, 622:188-194, 2023 Cited by PubMed: 37704723 DOI: 10.1038/s41586-023-06532-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation