7UUL

Crystal structure of aminoglycoside resistance enzyme ApmA, complex with kanamycin B and coenzyme A

Summary for 7UUL

• Entry DOI: 10.2210/pdb7uul/pdb
• Related: 7UUJ 7UUK 7UUM 7UUN 7UUO
• Descriptor: Aminocyclitol acetyltransferase ApmA, (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, COENZYME A, ... (7 entities in total)
• Functional Keywords: xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 6
• Total formula weight: 196205.37

Authors

Stogios, P.J.,Evdokimova, E.,Di Leo, R.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID),Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-04-28, release date: 2022-11-02, Last modification date: 2024-02-14)

• Primary citation: Bordeleau, E.,Stogios, P.J.,Evdokimova, E.,Koteva, K.,Savchenko, A.,Wright, G.D.; Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.; Nat.Chem.Biol., 20:234-242, 2024; PubMed: 37973888; DOI: 10.1038/s41589-023-01483-3

Experimental method

X-RAY DIFFRACTION (2.26 Å)