7UUK

Crystal structure of aminoglycoside resistance enzyme ApmA, complex with tobramycin

Summary for 7UUK

Entry DOI	10.2210/pdb7uuk/pdb
Related	7UUJ 7UUL 7UUM 7UUN 7UUO
Descriptor	Aminocyclitol acetyltransferase ApmA, TOBRAMYCIN, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	xat, xenobiotic acetyltransferase, left-handed beta helix, lbh, antibiotic resistance, aminoglycoside, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase, center for structural biology of infectious diseases, csbid
Biological source	Staphylococcus aureus
Total number of polymer chains	3
Total formula weight	95481.86
Authors	Stogios, P.J.,Evdokimova, E.,Di Leo, R.,Bordeleau, E.,Wright, G.D.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-04-28, release date: 2023-04-19, Last modification date: 2024-02-14)
Primary citation	Bordeleau, E.,Stogios, P.J.,Evdokimova, E.,Koteva, K.,Savchenko, A.,Wright, G.D. Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance. Nat.Chem.Biol., 20:234-242, 2024 Cited by PubMed: 37973888 DOI: 10.1038/s41589-023-01483-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation