7SO0

Crystal Structure of the Engineered Tick Evasin EVA-P974(F31A) Complexed to Human Chemokine CCL2

Summary for 7SO0

Entry DOI	10.2210/pdb7so0/pdb
Descriptor	Evasin P974, C-C motif chemokine 2 (3 entities in total)
Functional Keywords	inflammation, chemokine, tick evasin, immune system
Biological source	Amblyomma cajennense (Cayenne tick, Acarus cajennensis) More
Total number of polymer chains	2
Total formula weight	18298.99
Authors	Bhusal, R.P.,Devkota, S.R.,Aryal, P.,Wilce, M.C.J.,Stone, M.J. (deposition date: 2021-10-28, release date: 2022-03-16, Last modification date: 2023-10-18)
Primary citation	Bhusal, R.P.,Aryal, P.,Devkota, S.R.,Pokhrel, R.,Gunzburg, M.J.,Foster, S.R.,Lim, H.D.,Payne, R.J.,Wilce, M.C.J.,Stone, M.J. Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed: 35217625 DOI: 10.1073/pnas.2122105119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation