7SO0

Crystal Structure of the Engineered Tick Evasin EVA-P974(F31A) Complexed to Human Chemokine CCL2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Evasin P974	polymer	85	9626.0	1	UniProt (A0A023FDY8) Pfam (PF19429) In PDB	Amblyomma cajennense (Cayenne tick Acarus cajennensis)
2	B	C-C motif chemokine 2	polymer	76	8673.0	1	UniProt (P13500) Pfam (PF00048) In PDB	Homo sapiens (Human)	HC11,Monocyte chemoattractant protein 1,Monocyte chemotactic and activating factor,MCAF,Monocyte chemotactic protein 1,MCP-1,Monocyte secretory protein JE,Small-inducible cytokine A2
3		water	water		18.0	129	Chemie (HOH)

Sequence modifications

A: 1 - 85 (UniProt: A0A023FDY8)

PDB	External Database	Details
Ala 23	Phe 52	engineered mutation

B: 1 - 76 (UniProt: P13500)

PDB	External Database	Details
Ala 8	Pro 31	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	18299.0
All*	Total formula weight	18299.0

*Water molecules are not included.