7SHN

Cryo-EM structure of oleoyl-CoA-bound human peroxisomal fatty acid transporter ABCD1

Summary for 7SHN

• Entry DOI: 10.2210/pdb7shn/pdb
• EMDB information: 25130 25131
• Descriptor: ATP-binding cassette sub-family D member 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) (2 entities in total)
• Functional Keywords: abc transporter, abcd, acyl-coa transport, lipid transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 161277.63

Authors

Wang, R.,Li, X. (deposition date: 2021-10-09, release date: 2021-11-03, Last modification date: 2022-02-16)

• Primary citation: Wang, R.,Qin, Y.,Li, X.; Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.; Cell Res., 32:214-217, 2022; PubMed: 34754073; DOI: 10.1038/s41422-021-00585-8

Experimental method

ELECTRON MICROSCOPY (3.1 Å)