7SCE

Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-2 octasaccharide substrate and co-factor product PAP

Summary for 7SCE

Entry DOI	10.2210/pdb7sce/pdb
Descriptor	Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	sulfotransferase, heparan sulfate, oligosaccharide, complex, transferase, transferase-substrate complex, transferase/substrate
Biological source	Escherichia coli More
Total number of polymer chains	1
Total formula weight	44838.95
Authors	Wander, R.,Kaminski, A.M.,Krahn, J.M.,Liu, J.,Pedersen, L.C. (deposition date: 2021-09-27, release date: 2022-01-19, Last modification date: 2023-10-18)
Primary citation	Wander, R.,Kaminski, A.M.,Wang, Z.,Stancanelli, E.,Xu, Y.,Pagadala, V.,Li, J.,Krahn, J.M.,Pham, T.Q.,Liu, J.,Pedersen, L.C. Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate Acs Catalysis, 11:14956-14966, 2021 Cited by DOI: 10.1021/acscatal.1c04520 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation