7RTB

Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)

Summary for 7RTB

• Entry DOI: 10.2210/pdb7rtb/pdb
• EMDB information: 24680
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: glucagon-like peptide-1 receptor (glp-1r), peptide-19 cryo-em, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 163991.76

Authors

Johnson, R.M.,Danev, R.,Sexton, P.M.,Wootten, D. (deposition date: 2021-08-12, release date: 2021-10-06)

• Primary citation: Johnson, R.M.,Zhang, X.,Piper, S.J.,Nettleton, T.J.,Vandekolk, T.H.,Langmead, C.J.,Danev, R.,Sexton, P.M.,Wootten, D.; Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.; Biochem.Biophys.Res.Commun., 578:84-90, 2021; PubMed: 34547628; DOI: 10.1016/j.bbrc.2021.09.016

Experimental method

ELECTRON MICROSCOPY (2.14 Å)