7RD5

Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab

Summary for 7RD5

• Entry DOI: 10.2210/pdb7rd5/pdb
• Related: 7RDB
• Descriptor: 1C12 Fab Light Chain, 1C12 Fab Heavy Chain, Tetraspanin-15 (3 entities in total)
• Functional Keywords: tetraspanin, membrane protein, protein trafficking, cell adhesion
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 6
• Total formula weight: 126423.63

Authors

Lipper, C.H.,Gabriel, K.H.,Seegar, T.C.M.,Durr, K.L.,Tomlinson, M.G.,Blacklow, S.C. (deposition date: 2021-07-09, release date: 2021-11-03, Last modification date: 2023-10-18)

• Primary citation: Lipper, C.H.,Gabriel, K.H.,Seegar, T.C.M.,Durr, K.L.,Tomlinson, M.G.,Blacklow, S.C.; Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.; Structure, 30:206-214.e4, 2022; PubMed: 34739841; DOI: 10.1016/j.str.2021.10.007

Experimental method

X-RAY DIFFRACTION (3.6 Å)