7RCO

Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab

Summary for 7RCO

Entry DOI	10.2210/pdb7rco/pdb
Descriptor	Transforming growth factor beta-2, 4A11.V2 Fab Light Chain, 4A11.V2 Fab Heavy Chain, ... (4 entities in total)
Functional Keywords	tgf-beta-2, conformational antibody, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	121379.65
Authors	Yin, J.,Lupardus, P.J.,Sudhamsu, J. (deposition date: 2021-07-07, release date: 2021-09-29, Last modification date: 2023-10-18)
Primary citation	Liang, W.C.,Yin, J.,Lupardus, P.,Zhang, J.,Loyet, K.M.,Sudhamsu, J.,Wu, Y. Dramatic activation of an antibody by a single amino acid change in framework. Sci Rep, 11:22365-22365, 2021 Cited by PubMed: 34785671 DOI: 10.1038/s41598-021-01530-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation