7PR6

Crystal structure of E. coli beta-glucuronidase in complex with covalent inhibitor ME727

This is a non-PDB format compatible entry.

Summary for 7PR6

• Entry DOI: 10.2210/pdb7pr6/pdb
• Descriptor: Beta-glucuronidase, (2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid (3 entities in total)
• Functional Keywords: glycoside hydrolase, carbohydrate, glucuronidase, gh2
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 2
• Total formula weight: 137167.41

Authors

Wu, L.,Armstrong, Z.,Davies, G.J. (deposition date: 2021-09-20, release date: 2022-08-03, Last modification date: 2024-01-31)

• Primary citation: de Boer, C.,Armstrong, Z.,Lit, V.A.J.,Barash, U.,Ruijgrok, G.,Boyango, I.,Weitzenberg, M.M.,Schroder, S.P.,Sarris, A.J.C.,Meeuwenoord, N.J.,Bule, P.,Kayal, Y.,Ilan, N.,Codee, J.D.C.,Vlodavsky, I.,Overkleeft, H.S.,Davies, G.J.,Wu, L.; Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.; Proc.Natl.Acad.Sci.USA, 119:e2203167119-e2203167119, 2022; PubMed: 35881786; DOI: 10.1073/pnas.2203167119

Experimental method

X-RAY DIFFRACTION (1.99 Å)