7PI6

Trypanosoma brucei ISG65 bound to human complement C3d

Summary for 7PI6

• Entry DOI: 10.2210/pdb7pi6/pdb
• Descriptor: 65 kDa invariant surface glycoprotein, Complement C3dg fragment, GLYCEROL, ... (5 entities in total)
• Functional Keywords: complement, innate immunity, host-pathogen, sleeping sickness, immune system
• Biological source: Trypanosoma brucei brucei (strain 927/4 GUTat10.1); More
• Total number of polymer chains: 4
• Total formula weight: 154743.35

Authors

Cook, A.D.,Higgins, M.K. (deposition date: 2021-08-19, release date: 2022-07-27, Last modification date: 2024-02-07)

• Primary citation: Macleod, O.J.S.,Cook, A.D.,Webb, H.,Crow, M.,Burns, R.,Redpath, M.,Seisenberger, S.,Trevor, C.E.,Peacock, L.,Schwede, A.,Kimblin, N.,Francisco, A.F.,Pepperl, J.,Rust, S.,Voorheis, P.,Gibson, W.,Taylor, M.C.,Higgins, M.K.,Carrington, M.; Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.; Nat Commun, 13:5085-5085, 2022; PubMed: 36038546; DOI: 10.1038/s41467-022-32728-9

Experimental method

X-RAY DIFFRACTION (2.6 Å)