7PGK

HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS

Summary for 7PGK

Entry DOI	10.2210/pdb7pgk/pdb
Related PRD ID	PRD_900013
Descriptor	Hedgehog-interacting protein, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose (2 entities in total)
Functional Keywords	hhip, hedgehog, morphogen, signalling, glycosaminoglycan, cholesterol, palmitate, secreted, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	22067.94
Authors	Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinuskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C. (deposition date: 2021-08-14, release date: 2021-12-15, Last modification date: 2021-12-22)
Primary citation	Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinauskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12:7171-7171, 2021 Cited by PubMed: 34887403 DOI: 10.1038/s41467-021-27475-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation