7P6K
Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic nanobody Sb5
Summary for 7P6K
| Entry DOI | 10.2210/pdb7p6k/pdb |
| EMDB information | 13202 13203 13208 13212 13213 13230 |
| Descriptor | Volume-regulated anion channel subunit LRRC8A, synthetic nanobody Sb5 (2 entities in total) |
| Functional Keywords | lrrc8 family, volume-regulated anion channel, leucine-rich repeat, sybody, cryo-em, membrane protein |
| Biological source | Mus musculus (Mouse) More |
| Total number of polymer chains | 9 |
| Total formula weight | 611825.47 |
| Authors | Deneka, D.,Rutz, S.,Sawicka, M. (deposition date: 2021-07-16, release date: 2021-09-15, Last modification date: 2021-10-13) |
| Primary citation | Deneka, D.,Rutz, S.,Hutter, C.A.J.,Seeger, M.A.,Sawicka, M.,Dutzler, R. Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains. Nat Commun, 12:5435-5435, 2021 Cited by PubMed: 34521847DOI: 10.1038/s41467-021-25742-w PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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