7P5Z

Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase

This is a non-PDB format compatible entry.

Summary for 7P5Z

• Entry DOI: 10.2210/pdb7p5z/pdb
• Related: 7P30
• EMDB information: 13176 13211
• Descriptor: DNA replication licensing factor MCM2, DNA (53-MER), ADENOSINE-5'-TRIPHOSPHATE, ... (14 entities in total)
• Functional Keywords: kinase, mcm2-7 helicase, nucleoprotein complex, dna replication, replication
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 16
• Total formula weight: 1401822.80

Authors

Greiwe, J.F.,Miller, T.C.R.,Martino, F.,Costa, A. (deposition date: 2021-07-15, release date: 2022-02-02)

• Primary citation: Greiwe, J.F.,Miller, T.C.R.,Locke, J.,Martino, F.,Howell, S.,Schreiber, A.,Nans, A.,Diffley, J.F.X.,Costa, A.; Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase.; Nat.Struct.Mol.Biol., 29:10-20, 2022; PubMed: 34963704; DOI: 10.1038/s41594-021-00698-z

Experimental method

ELECTRON MICROSCOPY (3.3 Å)