7P0W

Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing thymine opposite to lesion)

Summary for 7P0W

• Entry DOI: 10.2210/pdb7p0w/pdb
• Descriptor: N-glycosylase/DNA lyase, DNA (5'-D(*TP*TP*TP*(PED)P*TP*TP*TP*CP*T)-3'), DNA (5'-D(*AP*GP*AP*AP*AP*TP*AP*AP*A)-3'), ... (6 entities in total)
• Functional Keywords: 8-oxoguanine dna glycosylase, agog, pyrococcus abyssi, trapped double-stranded dna intermediate, hydrolase
• Biological source: Pyrococcus abyssi (strain GE5 / Orsay); More
• Total number of polymer chains: 3
• Total formula weight: 33601.42

Authors

Coste, F.,Goffinont, S.,Flament, D.,Castaing, B. (deposition date: 2021-06-30, release date: 2022-07-13, Last modification date: 2024-01-31)

• Primary citation: Franck, C.,Stephane, G.,Julien, C.,Virginie, G.,Martine, G.,Norbert, G.,Fabrice, C.,Didier, F.,Josef, S.M.,Bertrand, C.; Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing.; Nucleic Acids Res., 50:11072-11092, 2022; PubMed: 36300625; DOI: 10.1093/nar/gkac932

Experimental method

X-RAY DIFFRACTION (1.12 Å)