7ORC

Human Aldehyde Oxidase in complex with Raloxifene

Summary for 7ORC

• Entry DOI: 10.2210/pdb7orc/pdb
• Related: 7OPN
• Descriptor: Aldehyde oxidase, FE2/S2 (INORGANIC) CLUSTER, PHOSPHONIC ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER, ... (8 entities in total)
• Functional Keywords: human aldehyde oxidase, complex, inhibitor, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 301882.62

Authors

Mota, C.,Coelho, C.,Santos Silva, T.,Romao, M.J. (deposition date: 2021-06-05, release date: 2021-09-01, Last modification date: 2024-01-31)

• Primary citation: Mota, C.,Diniz, A.,Coelho, C.,Santos-Silva, T.,Esmaeeli, M.,Leimkuhler, S.,Cabrita, E.J.,Marcelo, F.,Romao, M.J.; Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.; J.Med.Chem., 64:13025-13037, 2021; PubMed: 34415167; DOI: 10.1021/acs.jmedchem.1c01125

Experimental method

X-RAY DIFFRACTION (2.7 Å)