7OPN

Human Aldehyde Oxidase SNP R1231H in complex with Raloxifene

Summary for 7OPN

• Entry DOI: 10.2210/pdb7opn/pdb
• Related: 7ORC
• Descriptor: Aldehyde oxidase, DIMETHYL SULFOXIDE, FE2/S2 (INORGANIC) CLUSTER, ... (11 entities in total)
• Functional Keywords: human aldehyde oxidase, single nucleotide polymorphism, complex, inhibitor, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 302261.18

Authors

Mota, C.,Coelho, C.,Santos Silva, T.,Romao, M.J. (deposition date: 2021-06-01, release date: 2021-09-01, Last modification date: 2024-01-31)

• Primary citation: Mota, C.,Diniz, A.,Coelho, C.,Santos-Silva, T.,Esmaeeli, M.,Leimkuhler, S.,Cabrita, E.J.,Marcelo, F.,Romao, M.J.; Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.; J.Med.Chem., 64:13025-13037, 2021; PubMed: 34415167; DOI: 10.1021/acs.jmedchem.1c01125

Experimental method

X-RAY DIFFRACTION (2.6 Å)