7OCM

K1K1H6, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic

Summary for 7OCM

Entry DOI	10.2210/pdb7ocm/pdb
Descriptor	Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	met receptor agonist, hgf/sf kringle 1 dimer, hgf/sf-derived recombinant protein, met-activator, regeneration of epithelial tissue and organs, engineered growth factor, de novo protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	20538.15
Authors	de Jonge, H.,de Nola, G.,Gherardi, E. (deposition date: 2021-04-27, release date: 2021-07-07, Last modification date: 2024-02-07)
Primary citation	de Nola, G.,Leclercq, B.,Mougel, A.,Taront, S.,Simonneau, C.,Forneris, F.,Adriaenssens, E.,Drobecq, H.,Iamele, L.,Dubuquoy, L.,Melnyk, O.,Gherardi, E.,de Jonge, H.,Vicogne, J. Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist. Life Sci Alliance, 5:-, 2022 Cited by PubMed: 35905995 DOI: 10.26508/lsa.202201424 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation