7MGQ

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

Summary for 7MGQ

Entry DOI	10.2210/pdb7mgq/pdb
Descriptor	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, MAGNESIUM ION (3 entities in total)
Functional Keywords	isomerase, ligand, complex, structural protein
Biological source	Cryptococcus neoformans
Total number of polymer chains	4
Total formula weight	262032.13
Authors	Wizrah, M.S.,Chua, S.M.H.,Luo, Z.,Manik, M.K.,Pan, M.,Whyte, J.M.,Robertson, A.B.,Kappler, U.,Kobe, B.,Fraser, J.A. (deposition date: 2021-04-13, release date: 2022-04-20, Last modification date: 2023-10-18)
Primary citation	Wizrah, M.S.I.,Chua, S.M.H.,Luo, Z.,Manik, M.K.,Pan, M.,Whyte, J.M.L.,Robertson, A.A.B.,Kappler, U.,Kobe, B.,Fraser, J.A. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J.Biol.Chem., 298:102453-102453, 2022 Cited by PubMed: 36063996 DOI: 10.1016/j.jbc.2022.102453 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation