7MBX

Human Cholecystokinin 1 receptor (CCK1R) Gs complex

Summary for 7MBX

• Entry DOI: 10.2210/pdb7mbx/pdb
• EMDB information: 23749
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
• Functional Keywords: gpcr, membrane protein, membrane protein-signaling protein complex, membrane protein/signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 156607.26

Authors

Mobbs, J.I.,Belousoff, M.J.,Danev, R.,Thal, D.M.,Sexton, P.M. (deposition date: 2021-04-01, release date: 2021-05-26, Last modification date: 2021-07-14)

• Primary citation: Mobbs, J.I.,Belousoff, M.J.,Harikumar, K.G.,Piper, S.J.,Xu, X.,Furness, S.G.B.,Venugopal, H.,Christopoulos, A.,Danev, R.,Wootten, D.,Thal, D.M.,Miller, L.J.,Sexton, P.M.; Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.; Plos Biol., 19:e3001295-e3001295, 2021; PubMed: 34086670; DOI: 10.1371/journal.pbio.3001295

Experimental method

ELECTRON MICROSCOPY (1.95 Å)