7MBX
Human Cholecystokinin 1 receptor (CCK1R) Gs complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Rat) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | N | Nanobody35 | polymer | 138 | 15140.7 | 1 | Lama glama | ||
5 | P | Cholecystokinin-8 | polymer | 9 | 1142.3 | 1 | UniProt (P06307) In PDB | Homo sapiens | CCK-8 |
6 | R | Cholecystokinin receptor type A | polymer | 435 | 48860.0 | 1 | UniProt (P32238) Pfam (PF09193) Pfam (PF00001) In PDB | Homo sapiens (Human) | CCK-A receptor,CCK-AR,Cholecystokinin-1 receptor,CCK1-R |
7 | R | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
8 | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
P: 1 - 8 (UniProt: P06307)
R: 2 - 428 (UniProt: P32238)
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | conflict |
Ala 226 | Gly 226 | conflict |
Ala 268 | Glu 268 | conflict |
Lys 271 | Asn 271 | conflict |
Asp 274 | Lys 274 | conflict |
Lys 280 | Arg 280 | conflict |
Asp 284 | Thr 284 | conflict |
Thr 285 | Ile 285 | conflict |
Ser 366 | Ala 366 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Nh2 9 | - | amidation |
PDB | External Database | Details |
---|---|---|
His 429 | - | expression tag |
His 430 | - | expression tag |
His 431 | - | expression tag |
His 432 | - | expression tag |
His 433 | - | expression tag |
His 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 156120.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 486.7 | |
All* | Total formula weight | 156607.3 |