7M95

Bovine sigma-2 receptor bound to Z1241145220

Summary for 7M95

• Entry DOI: 10.2210/pdb7m95/pdb
• Descriptor: Sigma intracellular receptor 2, 3-[1-(3-phenylpropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine, CHOLESTEROL, ... (5 entities in total)
• Functional Keywords: receptor, sterol, dimer, membrane protein
• Biological source: Bos taurus (Bovine)
• Total number of polymer chains: 2
• Total formula weight: 44690.16

Authors

Alon, A.,Kruse, A.C. (deposition date: 2021-03-30, release date: 2021-12-15, Last modification date: 2023-10-18)

• Primary citation: Alon, A.,Lyu, J.,Braz, J.M.,Tummino, T.A.,Craik, V.,O'Meara, M.J.,Webb, C.M.,Radchenko, D.S.,Moroz, Y.S.,Huang, X.P.,Liu, Y.,Roth, B.L.,Irwin, J.J.,Basbaum, A.I.,Shoichet, B.K.,Kruse, A.C.; Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.; Nature, 600:759-764, 2021; PubMed: 34880501; DOI: 10.1038/s41586-021-04175-x

Experimental method

X-RAY DIFFRACTION (2.41 Å)