7M95
Bovine sigma-2 receptor bound to Z1241145220
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0005764 | cellular_component | lysosome |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005791 | cellular_component | rough endoplasmic reticulum |
A | 0005886 | cellular_component | plasma membrane |
A | 0008142 | molecular_function | oxysterol binding |
A | 0015485 | molecular_function | cholesterol binding |
A | 0016020 | cellular_component | membrane |
A | 0030867 | cellular_component | rough endoplasmic reticulum membrane |
A | 0031965 | cellular_component | nuclear membrane |
A | 0032377 | biological_process | regulation of intracellular lipid transport |
A | 0032383 | biological_process | regulation of intracellular cholesterol transport |
A | 0042632 | biological_process | cholesterol homeostasis |
A | 0090303 | biological_process | positive regulation of wound healing |
A | 0140077 | biological_process | positive regulation of lipoprotein transport |
B | 0005634 | cellular_component | nucleus |
B | 0005764 | cellular_component | lysosome |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005791 | cellular_component | rough endoplasmic reticulum |
B | 0005886 | cellular_component | plasma membrane |
B | 0008142 | molecular_function | oxysterol binding |
B | 0015485 | molecular_function | cholesterol binding |
B | 0016020 | cellular_component | membrane |
B | 0030867 | cellular_component | rough endoplasmic reticulum membrane |
B | 0031965 | cellular_component | nuclear membrane |
B | 0032377 | biological_process | regulation of intracellular lipid transport |
B | 0032383 | biological_process | regulation of intracellular cholesterol transport |
B | 0042632 | biological_process | cholesterol homeostasis |
B | 0090303 | biological_process | positive regulation of wound healing |
B | 0140077 | biological_process | positive regulation of lipoprotein transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue ZNC A 201 |
Chain | Residue |
A | MET28 |
A | ASP29 |
A | TYR50 |
A | PHE69 |
A | GLU73 |
A | GLN77 |
A | THR110 |
A | TYR147 |
A | TYR150 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue CLR A 202 |
Chain | Residue |
A | LEU38 |
A | TYR39 |
A | LEU43 |
A | LEU74 |
A | VAL75 |
A | ILE156 |
A | OLC208 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue OLC A 203 |
Chain | Residue |
A | PRO79 |
A | GLN138 |
A | LEU141 |
A | PHE142 |
A | LEU152 |
A | OLC205 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue OLC A 204 |
Chain | Residue |
A | PHE76 |
A | HIS106 |
A | OLC205 |
B | THR109 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue OLC A 205 |
Chain | Residue |
A | PHE76 |
A | PRO79 |
A | PHE80 |
A | OLC203 |
A | OLC204 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue OLC A 206 |
Chain | Residue |
A | TRP12 |
A | LEU19 |
A | PHE89 |
A | OLC207 |
B | PHE16 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue OLC A 207 |
Chain | Residue |
A | LEU19 |
A | PHE89 |
A | OLC206 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue OLC A 208 |
Chain | Residue |
A | PRO35 |
A | ASP37 |
A | LEU38 |
A | PHE160 |
A | ASN164 |
A | PRO165 |
A | CLR202 |
site_id | AC9 |
Number of Residues | 11 |
Details | binding site for residue ZNC B 201 |
Chain | Residue |
B | HIS21 |
B | MET28 |
B | ASP29 |
B | TYR50 |
B | PHE69 |
B | GLU73 |
B | GLN77 |
B | THR110 |
B | TYR147 |
B | TYR150 |
B | HOH302 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue OLC B 202 |
Chain | Residue |
A | TRP12 |
B | TRP12 |
B | PHE89 |
B | LYS90 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue OLC B 203 |
Chain | Residue |
A | ILE112 |
B | ILE102 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue OLC B 204 |
Chain | Residue |
B | LEU38 |
B | PRO40 |
B | LEU78 |
B | LEU159 |
B | ARG163 |
B | HOH314 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 34 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q12155 |
Chain | Residue | Details |
A | MET1-GLY9 | |
A | LYS90-PRO99 | |
B | MET1-GLY9 | |
B | LYS90-PRO99 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
Chain | Residue | Details |
A | LEU10-LEU30 | |
B | LEU10-LEU30 |
site_id | SWS_FT_FI3 |
Number of Residues | 114 |
Details | TOPO_DOM: Lumenal => ECO:0000250|UniProtKB:Q12155 |
Chain | Residue | Details |
A | GLN31-SER68 | |
A | ASP121-LEU141 | |
B | GLN31-SER68 | |
B | ASP121-LEU141 |
site_id | SWS_FT_FI4 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
Chain | Residue | Details |
A | PHE69-PHE89 | |
B | PHE69-PHE89 |
site_id | SWS_FT_FI5 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
Chain | Residue | Details |
A | ALA100-LEU120 | |
B | ALA100-LEU120 |
site_id | SWS_FT_FI6 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
Chain | Residue | Details |
A | PHE142-VAL162 | |
B | PHE142-VAL162 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34880501, ECO:0007744|PDB:7MFI |
Chain | Residue | Details |
A | VAL75 | |
A | GLN77 | |
B | VAL75 | |
B | GLN77 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | SITE: Likely important for receptor folding => ECO:0000250|UniProtKB:Q5BJF2 |
Chain | Residue | Details |
A | ASP56 | |
B | ASP56 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | SITE: Important for 20(S)-OHC binding and stereoselectivity => ECO:0000250|UniProtKB:Q5BJF2 |
Chain | Residue | Details |
A | TYR150 | |
B | TYR150 |