7LOV

Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and noeuromycin

Summary for 7LOV

Entry DOI	10.2210/pdb7lov/pdb
Descriptor	Toxin B, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	inhibitors, tcdb, toxin, kinetic isotope effects, kies, drug design, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Clostridioides difficile (Peptoclostridium difficile)
Total number of polymer chains	2
Total formula weight	130332.68
Authors	Harijan, R.K.,Paparella, A.S.,Aboulache, B.L.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2021-02-10, release date: 2021-11-17, Last modification date: 2023-10-18)
Primary citation	Paparella, A.S.,Aboulache, B.L.,Harijan, R.K.,Potts, K.S.,Tyler, P.C.,Schramm, V.L. Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nat Commun, 12:6285-6285, 2021 Cited by PubMed: 34725358 DOI: 10.1038/s41467-021-26580-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation