7KSK

Thiophenyl-Pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

Summary for 7KSK

Entry DOI	10.2210/pdb7ksk/pdb
Descriptor	Mitogen-activated protein kinase 10, 4-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(oxetan-3-yl)thiophene-2-carboxamide (3 entities in total)
Functional Keywords	jnk3, kinase inhibitor, alzheimer disease, pyrazolourea, neurodegeneration, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	53067.20
Authors	Park, H. (deposition date: 2020-11-23, release date: 2021-03-03, Last modification date: 2023-10-18)
Primary citation	Feng, Y.,Park, H.,Bauer, L.,Ryu, J.C.,Yoon, S.O. Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors. Acs Med.Chem.Lett., 12:24-29, 2021 Cited by PubMed: 33488960 DOI: 10.1021/acsmedchemlett.0c00533 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation