7KSK

Thiophenyl-Pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 10	polymer	464	52649.3	1	UniProt (P53779) Pfam (PF00069) In PDB	Homo sapiens (Human)	MAPK 10,MAP kinase p49 3F12,Stress-activated protein kinase 1b,SAPK1b,Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3
2	A	4-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(oxetan-3-yl)thiophene-2-carboxamide	non-polymer		417.9	1	Chemie (X3V)
3		water	water		18.0	53	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52649.3
Non-Polymers*	Number of molecules	1
	Total formula weight	417.9
All*	Total formula weight	53067.2

*Water molecules are not included.