7KGX

Structure of PQS Response Protein PqsE in Complex with 4-(3-(2-methyl-2-morpholinobutyl)ureido)-N-(thiazol-2-yl)benzamide

Summary for 7KGX

• Entry DOI: 10.2210/pdb7kgx/pdb
• Related: 7KGW
• Descriptor: 2-aminobenzoylacetyl-CoA thioesterase, FE (III) ION, 4-({[(2R)-2-methyl-2-(morpholin-4-yl)butyl]carbamoyl}amino)-N-(1,3-thiazol-2-yl)benzamide, ... (4 entities in total)
• Functional Keywords: quorum sensing, pqs, pqse, inhibitor, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 1
• Total formula weight: 35161.79

Authors

Jeffrey, P.D.,Taylor, I.R.,Bassler, B.L. (deposition date: 2020-10-19, release date: 2021-05-05, Last modification date: 2023-10-18)

• Primary citation: Taylor, I.R.,Paczkowski, J.E.,Jeffrey, P.D.,Henke, B.R.,Smith, C.D.,Bassler, B.L.; Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production.; Acs Chem.Biol., 16:740-752, 2021; PubMed: 33793200; DOI: 10.1021/acschembio.1c00049

Experimental method

X-RAY DIFFRACTION (2 Å)