7KBT

Factor VIII in complex with the anti-C2 domain antibody, G99

Summary for 7KBT

• Entry DOI: 10.2210/pdb7kbt/pdb
• Related: 4KI5 6MF0
• Descriptor: Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII, G99 heavy chain, G99 light chain, ... (8 entities in total)
• Functional Keywords: antibody, inhibitor, blood clotting, blood clotting-immune system complex, blood clotting/immune system
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 3
• Total formula weight: 217118.69

Authors

Ronayne, E.K.,Gish, J.,Wilson, C.,Peters, S.,Spencer, H.T.,Spiegel, P.C.,Childers, K.C. (deposition date: 2020-10-02, release date: 2020-11-18, Last modification date: 2023-10-18)

• Primary citation: Ronayne, E.K.,Peters, S.C.,Gish, J.S.,Wilson, C.,Spencer, H.T.,Doering, C.B.,Lollar, P.,Spiegel, P.C.,Childers, K.C.; Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor; Front Immunol, 12:2260-, 2021; DOI: 10.3389/fimmu.2021.697602

Experimental method

X-RAY DIFFRACTION (4.15 Å)