4KI5
Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99
Summary for 4KI5
Entry DOI | 10.2210/pdb4ki5/pdb |
Descriptor | MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN, MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN, MURINE MONOCLONAL G99 FAB HEAVY CHAIN, ... (6 entities in total) |
Functional Keywords | immunoglobulin fold, discoidin fold, antibody, blood coagulation factor, antigen binding, blood plasma, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00451 |
Total number of polymer chains | 5 |
Total formula weight | 115198.31 |
Authors | Walter, J.D.,Meeks, S.L.,Healey, J.F.,Lollar, P.,Spiegel, P.C. (deposition date: 2013-05-01, release date: 2014-01-15) |
Primary citation | Walter, J.D.,Werther, R.A.,Brison, C.M.,Cragerud, R.K.,Healey, J.F.,Meeks, S.L.,Lollar, P.,Spiegel, P.C. Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes. Blood, 122:4270-4278, 2013 Cited by PubMed: 24085769DOI: 10.1182/blood-2013-08-519124 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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