7F0I

phosphodiesterase-9A in complex with inhibitor 4b

Summary for 7F0I

• Entry DOI: 10.2210/pdb7f0i/pdb
• Descriptor: Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 124534.46

Authors

Wu, Y.,Huang, Y.Y.,Luo, H.B. (deposition date: 2021-06-04, release date: 2022-04-13, Last modification date: 2023-11-29)

• Primary citation: Wu, Y.,Wang, Q.,Jiang, M.Y.,Huang, Y.Y.,Zhu, Z.,Han, C.,Tian, Y.J.,Zhang, B.,Luo, H.B.; Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis; J.Med.Chem., 64:9537-9549, 2021; DOI: 10.1021/acs.jmedchem.1c00862

Experimental method

X-RAY DIFFRACTION (2.70000890032 Å)