7EZR

Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase

Summary for 7EZR

Entry DOI	10.2210/pdb7ezr/pdb
Descriptor	Fructose-1,6-bisphosphatase 1, 5-ethyl-7-nitro-3-[3-oxidanylidene-3-(thiophen-2-ylsulfonylamino)propyl]-1H-indole-2-carboxylic acid, 1,6-di-O-phosphono-beta-D-fructofuranose (3 entities in total)
Functional Keywords	fructose-1, 6-bisphosphatase, indole-2-carboxylic acids, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	150716.09
Authors	Wang, X.Y.,Zhou, J.,Xu, B.L. (deposition date: 2021-06-01, release date: 2022-06-01, Last modification date: 2023-11-29)
Primary citation	Wang, X.,Zhao, R.,Ji, W.,Zhou, J.,Liu, Q.,Zhao, L.,Shen, Z.,Liu, S.,Xu, B. Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis. Acs Med.Chem.Lett., 13:118-127, 2022 Cited by PubMed: 35059131 DOI: 10.1021/acsmedchemlett.1c00613 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.27 Å)

Structure validation