7EAX

Crystal complex of p53-V272M and antimony ion

Summary for 7EAX

• Entry DOI: 10.2210/pdb7eax/pdb
• Descriptor: Cellular tumor antigen p53, ZINC ION, ANTIMONY (III) ION, ... (4 entities in total)
• Functional Keywords: tumor suppressor p53, structural stabilization, antitumor protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 88312.22

Authors

Lu, M.,Tang, Y. (deposition date: 2021-03-08, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Tang, Y.,Song, H.,Wang, Z.,Xiao, S.,Xiang, X.,Zhan, H.,Wu, L.,Wu, J.,Xing, Y.,Tan, Y.,Liang, Y.,Yan, N.,Li, Y.,Li, J.,Wu, J.,Zheng, D.,Jia, Y.,Chen, Z.,Li, Y.,Zhang, Q.,Zhang, J.,Zeng, H.,Tao, W.,Liu, F.,Wu, Y.,Lu, M.; Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.; Cell Rep, 39:110622-110622, 2022; PubMed: 35417717; DOI: 10.1016/j.celrep.2022.110622

Experimental method

X-RAY DIFFRACTION (2.55 Å)