7BW1

Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride

Summary for 7BW1

• Entry DOI: 10.2210/pdb7bw1/pdb
• Descriptor: 3-oxo-5-alpha-steroid 4-dehydrogenase 2, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, [[(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{S},3~{a}~{S},3~{b}~{S},5~{a}~{R},8~{S},9~{a}~{R},9~{b}~{S},11~{a}~{S})-1-(~{tert}-butylcarbamoyl)-9~{a},11~{a}-dimethyl-7-oxidanylidene-1,2,3,3~{a},3~{b},4,5,5~{a},6,8,9,9~{b},10,11-tetradecahydroindeno[5,4-f]quinolin-8-yl]-3-aminocarbonyl-4~{H}-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate, ... (4 entities in total)
• Functional Keywords: integral membrane protein, reductase, steroid, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30360.15

Authors

Xiao, Q.,Zhang, C.,Wei, Z. (deposition date: 2020-04-13, release date: 2020-08-05)

• Primary citation: Xiao, Q.,Wang, L.,Supekar, S.,Shen, T.,Liu, H.,Ye, F.,Huang, J.,Fan, H.,Wei, Z.,Zhang, C.; Structure of human steroid 5 alpha-reductase 2 with anti-androgen drug finasteride.; Res Sq, 2020; PubMed: 32702725; DOI: 10.21203/rs.3.rs-40159/v1

Experimental method

X-RAY DIFFRACTION (2.8 Å)