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7BW1

Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride

Functional Information from GO Data
ChainGOidnamespacecontents
A0003865molecular_function3-oxo-5-alpha-steroid 4-dehydrogenase activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006629biological_processlipid metabolic process
A0006694biological_processsteroid biosynthetic process
A0006702biological_processandrogen biosynthetic process
A0006706biological_processsteroid catabolic process
A0007267biological_processcell-cell signaling
A0007548biological_processsex differentiation
A0008202biological_processsteroid metabolic process
A0008209biological_processandrogen metabolic process
A0008584biological_processmale gonad development
A0009410biological_processresponse to xenobiotic stimulus
A0010033biological_processresponse to organic substance
A0014070biological_processresponse to organic cyclic compound
A0016020cellular_componentmembrane
A0016229molecular_functionsteroid dehydrogenase activity
A0016491molecular_functionoxidoreductase activity
A0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
A0018879biological_processbiphenyl metabolic process
A0018894biological_processdibenzo-p-dioxin metabolic process
A0018963biological_processphthalate metabolic process
A0021766biological_processhippocampus development
A0021854biological_processhypothalamus development
A0030154biological_processcell differentiation
A0030283molecular_functiontestosterone dehydrogenase [NAD(P)] activity
A0030539biological_processmale genitalia development
A0030540biological_processfemale genitalia development
A0031667biological_processresponse to nutrient levels
A0032354biological_processresponse to follicle-stimulating hormone
A0033218molecular_functionamide binding
A0033574biological_processresponse to testosterone
A0043025cellular_componentneuronal cell body
A0043434biological_processresponse to peptide hormone
A0047751molecular_function3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity
A0048545biological_processresponse to steroid hormone
A0060348biological_processbone development
A0061370biological_processtestosterone biosynthetic process
A0070852cellular_componentcell body fiber
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue OLC A 601
ChainResidue
AALA205
ALEU206
ATRP209
ALEU214

site_idAC2
Number of Residues31
Detailsbinding site for residue NDX A 602
ChainResidue
ATRP53
AGLU57
AARG94
ATYR98
AASN102
AGLY104
AARG105
AARG114
APHE118
AASN160
AASP164
ALEU167
AARG171
ASER177
ATYR178
AARG179
AASN193
APHE194
AGLU197
ATRP201
APHE219
ASER220
APHE223
AARG227
AHIS231
ATYR235
AALA24
ASER31
ATYR33
AGLY34
ALYS35

site_idAC3
Number of Residues9
Detailsbinding site for residue SO4 A 603
ChainResidue
APRO30
AGLY32
ATYR33
AGLY34
ALYS35
AHIS36
ATHR37
AARG227
AHIS231

site_idAC4
Number of Residues2
Detailsbinding site for residue SO4 A 604
ChainResidue
AHIS162
AGLY184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ASER8-ALA28
APRO72-PHE92
APHE146-ILE166
ALEU206-LEU226

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PDB entries from 2024-06-12

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