7BCT

ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation.

Summary for 7BCT

Entry DOI	10.2210/pdb7bct/pdb
Related	7BCQ 7BCS
EMDB information	12142 12143
Descriptor	Neutral amino acid transporter B(0) (1 entity in total)
Functional Keywords	solute carrier transporter, membrane protein, homology modeling, cancer metabolism, glutamine deprivation, cryo-em
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	169916.71
Authors	Garibsingh, R.A.,Ndaru, E.,Garaeva, A.A.,Shi, Y.,Zielewicz, L.,Bonomi, M.,Slotboom, D.J.,Paulino, C.,Grewer, C.,Schlessinger, A. (deposition date: 2020-12-21, release date: 2021-09-22, Last modification date: 2021-09-29)
Primary citation	Garibsingh, R.A.,Ndaru, E.,Garaeva, A.A.,Shi, Y.,Zielewicz, L.,Zakrepine, P.,Bonomi, M.,Slotboom, D.J.,Paulino, C.,Grewer, C.,Schlessinger, A. Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34507995 DOI: 10.1073/pnas.2104093118 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.37 Å)

Structure validation