7BCQ

ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation.

Summary for 7BCQ

Entry DOI	10.2210/pdb7bcq/pdb
EMDB information	12142
Descriptor	Neutral amino acid transporter B(0), 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid (2 entities in total)
Functional Keywords	solute carrier transporter, membrane protein, homology modeling, cancer metabolism, glutamine deprivation, cryo-em
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	170850.70
Authors	Garibsingh, R.A.,Ndaru, E.,Garaeva, A.A.,Shi, Y.,Zielewicz, L.,Bonomi, M.,Slotboom, D.J.,Paulino, C.,Grewer, C.,Schlessinger, A. (deposition date: 2020-12-21, release date: 2021-09-22, Last modification date: 2021-09-29)
Primary citation	Garibsingh, R.A.,Ndaru, E.,Garaeva, A.A.,Shi, Y.,Zielewicz, L.,Zakrepine, P.,Bonomi, M.,Slotboom, D.J.,Paulino, C.,Grewer, C.,Schlessinger, A. Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34507995 DOI: 10.1073/pnas.2104093118 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.43 Å)

Structure validation