7BC7

Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed

Summary for 7BC7

Entry DOI	10.2210/pdb7bc7/pdb
EMDB information	12141
Descriptor	Proton-coupled folate transporter, nanobody, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID (3 entities in total)
Functional Keywords	transporter folate proton symporter, membrane protein
Biological source	Gallus gallus (Chicken) More
Total number of polymer chains	2
Total formula weight	65253.99
Authors	Parker, J.L.,Deme, J.C.,Lea, S.M.,Newstead, S. (deposition date: 2020-12-18, release date: 2021-05-12, Last modification date: 2021-08-11)
Primary citation	Parker, J.L.,Deme, J.C.,Kuteyi, G.,Wu, Z.,Huo, J.,Goldman, I.D.,Owens, R.J.,Biggin, P.C.,Lea, S.M.,Newstead, S. Structural basis of antifolate recognition and transport by PCFT. Nature, 595:130-134, 2021 Cited by PubMed: 34040256 DOI: 10.1038/s41586-021-03579-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation