6ZPR

Solution structure of MLKL executioner domain in complex with a covalent inhibitor

Summary for 6ZPR

• Entry DOI: 10.2210/pdb6zpr/pdb
• Related: 6ZLE
• NMR Information: BMRB: 34528
• Descriptor: Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein, 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione (2 entities in total)
• Functional Keywords: necroptosis, lipid binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 18453.23

Authors

Ruebbelke, M.,Bauer, M.,Hamilton, J.,Binder, F.,Nar, H.,Zeeb, M. (deposition date: 2020-07-09, release date: 2020-12-16, Last modification date: 2021-01-06)

• Primary citation: Rubbelke, M.,Fiegen, D.,Bauer, M.,Binder, F.,Hamilton, J.,King, J.,Thamm, S.,Nar, H.,Zeeb, M.; Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.; Proc.Natl.Acad.Sci.USA, 117:33272-33281, 2020; PubMed: 33318170; DOI: 10.1073/pnas.2017406117

Experimental method

SOLUTION NMR